Formulation And Evaluation Of Sertraline Hydrochloride Tablet By Self Micro-Emulsifying Drug Delivery System For Solubility Enhancement

The purpose of this research is to design and formulate the Self-micro emulsifying drug delivery system (SMEDDS) poorly water-soluble Sertraline Hydrochloride (SRT). SRT commonly used selective serotonin reuptake inhibitor for management a number depressive disorders. Its applicability limited because extensive metabolism poor oral bioavailability 44 %. Solubility in different vehicles determined with help which ternary phase diagrams were constructed. Capmul MCM C8 EP (as oil phase), Cremophore RH 40 surfactant) Labrafil M 2125 CS co-surfactant) selected development liquid formulation. prepared was characterized globule size, TEM, transmittance study, stability analysis permeability. formulation converted solid by adsorption on Neusilin US2 convert into tablet most convenient route. Results evaluation characterization formulated T SMEDDS compared those pure drug. In-vitro dissolution study comparison that marketed indicates Tablet helps improve solubility.